Pathophysiological characteristics of melanoma in-transit metastasis in a lymphedema mouse model.
Identifieur interne : 003315 ( Main/Exploration ); précédent : 003314; suivant : 003316Pathophysiological characteristics of melanoma in-transit metastasis in a lymphedema mouse model.
Auteurs : Kohei Oashi [Japon] ; Hiroshi Furukawa ; Hiroshi Nishihara ; Michitaka Ozaki ; Akihiko Oyama ; Emi Funayama ; Toshihiko Hayashi ; Yuji Kuge ; Yuhei YamamotoSource :
- The Journal of investigative dermatology [ 1523-1747 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Antigène KI-67 (génétique), Luciferases (génétique), Lymphoedème (anatomopathologie), Lymphoedème (physiopathologie), Mesures de luminescence, Modèles animaux de maladie humaine, Mâle, Mélanome expérimental (physiopathologie), Mélanome expérimental (secondaire), Métastase lymphatique (anatomopathologie), Pronostic, Souris, Souris de lignée C57BL, Transplantation tumorale, Tumeurs cutanées (anatomopathologie), Tumeurs cutanées (physiopathologie), Tumeurs du poumon (physiopathologie), Tumeurs du poumon (secondaire), Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (physiologie).
- MESH :
- anatomopathologie : Lymphoedème, Métastase lymphatique, Tumeurs cutanées, Vaisseaux lymphatiques.
- génétique : Antigène KI-67, Luciferases.
- physiologie : Vaisseaux lymphatiques.
- physiopathologie : Lymphoedème, Mélanome expérimental, Tumeurs cutanées, Tumeurs du poumon.
- secondaire : Mélanome expérimental, Tumeurs du poumon.
- Animaux, Mesures de luminescence, Modèles animaux de maladie humaine, Mâle, Pronostic, Souris, Souris de lignée C57BL, Transplantation tumorale.
English descriptors
- KwdEn :
- Animals, Disease Models, Animal, Ki-67 Antigen (genetics), Luciferases (genetics), Luminescent Measurements, Lung Neoplasms (physiopathology), Lung Neoplasms (secondary), Lymphatic Metastasis (pathology), Lymphatic Vessels (pathology), Lymphatic Vessels (physiology), Lymphedema (pathology), Lymphedema (physiopathology), Male, Melanoma, Experimental (physiopathology), Melanoma, Experimental (secondary), Mice, Mice, Inbred C57BL, Neoplasm Transplantation, Prognosis, Skin Neoplasms (pathology), Skin Neoplasms (physiopathology).
- MESH :
- chemical , genetics : Ki-67 Antigen, Luciferases.
- pathology : Lymphatic Metastasis, Lymphatic Vessels, Lymphedema, Skin Neoplasms.
- physiology : Lymphatic Vessels.
- physiopathology : Lung Neoplasms, Lymphedema, Melanoma, Experimental, Skin Neoplasms.
- secondary : Lung Neoplasms, Melanoma, Experimental.
- Animals, Disease Models, Animal, Luminescent Measurements, Male, Mice, Mice, Inbred C57BL, Neoplasm Transplantation, Prognosis.
Abstract
In-transit metastasis (ITM) is a unique manifestation of intralymphatic tumor dissemination, characterized by the presence of melanoma cells between the primary lesion and the draining regional lymph node basin that is clinically associated with poor prognosis. In this study, we aimed to establish an experimental animal model of melanoma ITM, as research progress in this field has been hampered by a lack of suitable experimental models. We reproduced melanoma ITM in a mouse hind limb by transplanting melanoma cells into the footpad of a mouse with lymphedema (LE). The tumor cells at the ITM site were highly proliferative, and mice with ITMs were more likely than control mice to develop distant lymph node and lung metastases. Peritumoral lymphatic vessels and tumor-associated blood vessels were increased in the primary tumor site of the LE mice. Our established ITM melanoma mouse model enabled us to clarify the molecular determinants and pathophysiology of ITM. This ITM model is also comparable to the unfavorable clinical behavior of melanoma ITM in humans and, moreover, underlined the importance of lymphangiogenic factors in the tumor dissemination through the lymphatic system.
DOI: 10.1038/jid.2012.274
PubMed: 22951727
Affiliations:
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uniqKey="Nishihara H" first="Hiroshi" last="Nishihara">Hiroshi Nishihara</name></author><author><name sortKey="Ozaki, Michitaka" sort="Ozaki, Michitaka" uniqKey="Ozaki M" first="Michitaka" last="Ozaki">Michitaka Ozaki</name></author><author><name sortKey="Oyama, Akihiko" sort="Oyama, Akihiko" uniqKey="Oyama A" first="Akihiko" last="Oyama">Akihiko Oyama</name></author><author><name sortKey="Funayama, Emi" sort="Funayama, Emi" uniqKey="Funayama E" first="Emi" last="Funayama">Emi Funayama</name></author><author><name sortKey="Hayashi, Toshihiko" sort="Hayashi, Toshihiko" uniqKey="Hayashi T" first="Toshihiko" last="Hayashi">Toshihiko Hayashi</name></author><author><name sortKey="Kuge, Yuji" sort="Kuge, Yuji" uniqKey="Kuge Y" first="Yuji" last="Kuge">Yuji Kuge</name></author><author><name sortKey="Yamamoto, Yuhei" sort="Yamamoto, Yuhei" uniqKey="Yamamoto Y" first="Yuhei" last="Yamamoto">Yuhei Yamamoto</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date 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melanoma in-transit metastasis in a lymphedema mouse model.</title><author><name sortKey="Oashi, Kohei" sort="Oashi, Kohei" uniqKey="Oashi K" first="Kohei" last="Oashi">Kohei Oashi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Hokkaido at Sapporo (UHS), Sapporo, Japan. ko03252000@yahoo.co.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Hokkaido at Sapporo (UHS), Sapporo</wicri:regionArea><wicri:noRegion>Sapporo</wicri:noRegion></affiliation></author><author><name sortKey="Furukawa, Hiroshi" sort="Furukawa, Hiroshi" uniqKey="Furukawa H" first="Hiroshi" last="Furukawa">Hiroshi Furukawa</name></author><author><name sortKey="Nishihara, Hiroshi" sort="Nishihara, Hiroshi" uniqKey="Nishihara H" first="Hiroshi" last="Nishihara">Hiroshi Nishihara</name></author><author><name sortKey="Ozaki, Michitaka" sort="Ozaki, Michitaka" uniqKey="Ozaki M" first="Michitaka" last="Ozaki">Michitaka Ozaki</name></author><author><name sortKey="Oyama, Akihiko" sort="Oyama, Akihiko" uniqKey="Oyama A" first="Akihiko" last="Oyama">Akihiko Oyama</name></author><author><name sortKey="Funayama, Emi" sort="Funayama, Emi" uniqKey="Funayama E" first="Emi" last="Funayama">Emi Funayama</name></author><author><name sortKey="Hayashi, Toshihiko" sort="Hayashi, Toshihiko" uniqKey="Hayashi T" first="Toshihiko" last="Hayashi">Toshihiko Hayashi</name></author><author><name sortKey="Kuge, Yuji" sort="Kuge, Yuji" uniqKey="Kuge Y" first="Yuji" last="Kuge">Yuji Kuge</name></author><author><name sortKey="Yamamoto, Yuhei" sort="Yamamoto, Yuhei" uniqKey="Yamamoto Y" first="Yuhei" last="Yamamoto">Yuhei Yamamoto</name></author></analytic><series><title level="j">The Journal of investigative dermatology</title><idno type="eISSN">1523-1747</idno><imprint><date when="2013" 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(génétique)</term><term>Luciferases (génétique)</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (physiopathologie)</term><term>Mesures de luminescence</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Mélanome expérimental (physiopathologie)</term><term>Mélanome expérimental (secondaire)</term><term>Métastase lymphatique (anatomopathologie)</term><term>Pronostic</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Transplantation tumorale</term><term>Tumeurs cutanées (anatomopathologie)</term><term>Tumeurs cutanées (physiopathologie)</term><term>Tumeurs du poumon (physiopathologie)</term><term>Tumeurs du poumon (secondaire)</term><term>Vaisseaux lymphatiques (anatomopathologie)</term><term>Vaisseaux lymphatiques (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Ki-67 Antigen</term><term>Luciferases</term></keywords><keywords scheme="MESH" 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Neoplasms</term><term>Lymphedema</term><term>Melanoma, Experimental</term><term>Skin Neoplasms</term></keywords><keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Mélanome expérimental</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Lung Neoplasms</term><term>Melanoma, Experimental</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Luminescent Measurements</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Neoplasm Transplantation</term><term>Prognosis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Mesures de luminescence</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Pronostic</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Transplantation tumorale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In-transit metastasis (ITM) is a unique manifestation of intralymphatic tumor dissemination, characterized by the presence of melanoma cells between the primary lesion and the draining regional lymph node basin that is clinically associated with poor prognosis. In this study, we aimed to establish an experimental animal model of melanoma ITM, as research progress in this field has been hampered by a lack of suitable experimental models. We reproduced melanoma ITM in a mouse hind limb by transplanting melanoma cells into the footpad of a mouse with lymphedema (LE). The tumor cells at the ITM site were highly proliferative, and mice with ITMs were more likely than control mice to develop distant lymph node and lung metastases. Peritumoral lymphatic vessels and tumor-associated blood vessels were increased in the primary tumor site of the LE mice. Our established ITM melanoma mouse model enabled us to clarify the molecular determinants and pathophysiology of ITM. This ITM model is also comparable to the unfavorable clinical behavior of melanoma ITM in humans and, moreover, underlined the importance of lymphangiogenic factors in the tumor dissemination through the lymphatic system.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Funayama, Emi" sort="Funayama, Emi" uniqKey="Funayama E" first="Emi" last="Funayama">Emi Funayama</name><name sortKey="Furukawa, Hiroshi" sort="Furukawa, Hiroshi" uniqKey="Furukawa H" first="Hiroshi" last="Furukawa">Hiroshi Furukawa</name><name sortKey="Hayashi, Toshihiko" sort="Hayashi, Toshihiko" uniqKey="Hayashi T" first="Toshihiko" last="Hayashi">Toshihiko Hayashi</name><name sortKey="Kuge, Yuji" sort="Kuge, Yuji" uniqKey="Kuge Y" first="Yuji" last="Kuge">Yuji Kuge</name><name sortKey="Nishihara, Hiroshi" sort="Nishihara, Hiroshi" uniqKey="Nishihara H" first="Hiroshi" last="Nishihara">Hiroshi Nishihara</name><name sortKey="Oyama, Akihiko" sort="Oyama, Akihiko" uniqKey="Oyama A" first="Akihiko" last="Oyama">Akihiko Oyama</name><name sortKey="Ozaki, Michitaka" sort="Ozaki, Michitaka" uniqKey="Ozaki M" first="Michitaka" last="Ozaki">Michitaka Ozaki</name><name sortKey="Yamamoto, Yuhei" sort="Yamamoto, Yuhei" uniqKey="Yamamoto Y" first="Yuhei" last="Yamamoto">Yuhei Yamamoto</name></noCountry><country name="Japon"><noRegion><name sortKey="Oashi, Kohei" sort="Oashi, Kohei" uniqKey="Oashi K" first="Kohei" last="Oashi">Kohei Oashi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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